(S)-Coriolic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(S)-Coriolic acid (13(S)-HODE) ，亚油酸的15-脂氧合酶 (15-LOX) 代谢产物，作为内源性配体激活 PPARγ。(S)-Coriolic acid 是一种重要的细胞内信号剂，在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 诱导线粒体功能障碍 (mitochondrial dysfunction) 和气道上皮损伤。

(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.

(S)-Coriolic acid (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium.(S)-Coriolic acid (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation.

(S)-Coriolic acid (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury.Animal Model:BALB/c mice (6-8 weeks)Dosage:0-0.6 mg per mouse Administration:Intranasally once a day for 3 consecutive days Result:BALB/c mice developed features of mitochondrial dysfunction such as reduction in mitochondrial membrane potential, reduction in complex IV activity in lung mitochondria, and increase in the levels of cytochrome c in lung cytosol.

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Immunology/Inflammation

Lipoxygenase

Lipoxygenase | Mitochondrial Metabolism | PPAR

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29623-28-7

296.44

C18H32O3

>98% (HPLC)

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C(=C/C=C\CCCCCCCC(O)=O)\[C@H](CCCCC)O

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(-20℃)

With Ice Pack

≥ 2 years